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APTO-253 is a novel small molecule with potent anti-tumor activity in cancer cells via induction of the gene that expresses the Kr├╝ppel-like factor 4 (KLF4) master transcription factor, leading to cell cycle inhibition and programmed cell death....Quality confirmed by NMR,HPLC & MS.
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Panobinostat(LBH-589) is a broad-spectrum HDAC inhibitor; low nanomolar concentrations (IC50=5-20 nM) of LBH589 induced cell-cycle arrest, apoptosis, and histone (H3K9 and H4K8) hyperacetylation in MOLT-4 and Reh cell.
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AT9283 is a small molecule a multi-targeted inhibitor with IC50s of 4, 1.2, 1.1 and approximate 3 nM for Bcr-Abl(T3151), JAK2 and JAK3, Aurora A and Aurora B, respectively.
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